Colts quarterback Andrew Luck threw for 312 yards and three touchdowns in a 24-19 victory over the Baltimore Ravens.
The Colts (6-3) won their third straight game in Baltimore, where they had lost three straight.
Luck threw four touchdowns and had a season-high 12 rushes for 106 yards.
He was sacked four times, but the Colts were unable to convert any of those sacks into first downs.
Baltimore Ravens running back Terrance West (14 carries, 90 yards) had three catches for 45 yards.
New England Patriots cornerback Logan Ryan (five tackles) and running back Chris Ivory (nine carries, 74 yards) each had four catches for 47 yards.
The Patriots have won three of their past four games, including a 20-16 victory at Detroit on Nov. 6.
New England has won four of its past five games overall.
Indianapolis Colts wide receiver T.Y. Hilton (27 receptions, 1,084 yards) was also targeted four times.
Hilton has caught five of his past six targets for 75 yards and a touchdown.
The Colts have scored touchdowns on six of their last seven games.